At Overlook Medical Center in Summit, researchers seek a 'game changer' for ...
SUMMIT — Lee Radsch recalls her mother's last trip before she got sick. On the way up Interstate 95 from Florida, her father had to pull off and stop for days at a motel. Radsch's mother was ill, but it wasn't just a passing bug.
Her stomach was swelling as if she were pregnant.
The trip to visit friends and family in the Northeast was cut short and her mother ended up in a Massachusetts hospital.
The diagnosis: ovarian cancer.
Radsch never forgot how quickly her mother's health declined before she died in 1982 at age 64 after battling the disease for about a year. Like many ovarian cases, the symptoms didn't occur until it was too late for treatment.
"She woke up one morning — and she was stage 4," said Radsch who is from Chatham. "It's been on my mind because there's no way to tell you have it until you have it."
A new blood test in clinical trials that would detect the cancer in its earliest stages may give women a better chance than Radsch's mother had when she was diagnosed in the early 1980s.
Overlook Medical Center in Summit is one of six sites in the country participating in a study on the protein known as CA-125, an antigen that can be a calling card secreted by an ovarian tumor.
Currently, women are tested for the amount of CA-125 protein in their blood to assess the risk or presence of ovarian cancer. But research has shown the amount of the protein isn't the only important reading — cases go undetected and there can also be false positives. Instead, what might be more relevant is the relative change in the amount of the protein and the rate of increase. The clinical trial under way measures not the level of the protein in the blood but how that level is changing. If the tests prove accurate, they may offer an early screening tool and allow greater survival rates, experts said.
Last year, about 22,000 new cases of ovarian cancer were diagnosed in the United States, 15,000 of which were fatal, according to the Ovarian Cancer National Alliance. Seventy percent of the women who get the disease are diagnosed at stages 3 and 4.
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